Alexander-Arnold had to substituted after just 25 minutes of the game at Anfield after sustaining what appeared to be a hamstring problem.
Conor Bradley replaced Alexander-Arnold, who has started all of Liverpool’s Premier League games this season.
Alexander-Arnold’s substitution will raise concerns about his involvement with England during the upcoming international break.
The 26-year-old has been named in the England squad for their games against Greece and the Republic of Ireland.
Liverpool are next in action on November 24, when they host Southampton.
Arne Slot will be eager to have Alexander-Arnold available for the Champions League game at home to Real Madrid on November 27 and the huge Premier League encounter at home to Liverpool on December 1.
Liverpool took the lead through Darwin Nunez in the 20th minute as they looked to take advantage of Manchester City’s defeat to Brighton.
Alexander-Arnold’s future at Liverpool beyond this season remains uncertain, with the star yet to agree a new contract.
According to The Sun, Liverpool are reluctant to meet Alexander-Arnold’s wage demands amid interest from Real Madrid.
